Skip to main content
. 2026 Sep 22;16:1951597. doi: 10.3389/fonc.2026.1951597

Figure 2.

Scientific diagram illustrating platelet-derived miRNAs being packaged into vesicles and transferred to tumor cells, where they regulate pathways like ubiquitin-mediated proteolysis, Wnt, FoxO, autophagy, TGF-beta, and mTOR, influencing tumor cell proliferation and apoptosis.

Proposed mechanisms of platelet-derived miRNAs in tumor cells. Platelet-derived microparticles (PMPs) may deliver miR-24, miR-711, miR-600, miR-495-3p, miR-136-5p, miR-1293 into tumor cells. miR-24 recruits mt-Nd2 mRNA and Snora75 to the RNA-induced silencing complex (RISC), thereby inducing mitochondrial dysfunction. miR-711 and miR-600 enhance the expression of stemness-related genes, including NANOG, OCT4 and SOX2. miR-495-3p, miR-136-5p, and miR-1293 revealed enrichment in the regulation of Wnt signaling, together with pathways involving FoxO, ubiquitin-mediated proteolysis, autophagy, TGF-β, and mTOR. These mechanisms regulate tumor cell proliferation and tumor cell apoptosis. Solid arrows indicate experimentally supported relationships, whereas dashed arrows indicate proposed or predicted relationships that have not yet been experimentally confirmed.