Figure 4.

Relative CCR2 and CXCR3 mRNA expression in ARPE-19 cells in (A & B) normal glucose (5.5 mM) and (C & D) high glucose (30 mM) conditions, following treatment with bevacizumab (0.3 mg/mL), triamcinolone (1 mg/mL), and their combination (0.3 mg/mL + 1 mg/mL) for 48 hours. Data are shown as mean SEM of three independent biological replicates. Statistical significance was assessed using one-way ANOVA with Tukey's post-hoc test: P 0.05 (*), P 0.01 (**), P 0.001 (***). M, mannitol osmotic control; C, control; B, bevacizumab; T, triamcinolone; BT, combination.