TABLE 3.
Sequence differences between HPV-11 and representative skin (HPV-1 to -4) and genital (HPV-6, -16, and -18) HPV typesa
| Peptide | HPV type | Sequence |
|---|---|---|
| 30-45 | HPV-11 | T N I F Y H A S S S R L L A V |
| HPV-6b | ||
| HPV-1a | LTEL | |
| HPV-2a | V YG GT | |
| HPV-3 | YYGT | |
| HPV-4 | S L Y FG T ET | |
| HPV-16 | YG T | |
| HPV-18 | SGT | |
| 139-144 | HPV-11 | D N R V N V G M D Y K Q T Q L |
| HPV-6b | ||
| HPV-1a | SQT A FAM | |
| HPV-2a | GEI S | |
| HPV-3 | SDI S VN | |
| HPV-4 | Q DS LPM | |
| HPV-16 | E C I S | |
| HPV-18 | VDS V | |
| 186-201 | HPV-11 | E L I T S V I Q D G D M V D T |
| HPV-6b | ||
| HPV-1a | Q MEEMI | |
| HPV-2a | Q F T N T TEE | |
| HPV-3 | A P | |
| HPV-4 | V NYCI | |
| HPV-16 | N T | |
| HPV-18 | K N TL E | |
| 243-258 | HPV-11 | L F F Y L R K E Q M F A R H F |
| HPV-6b | F | |
| HPV-1a | MF ARY T | |
| HPV-2a | MSRT | |
| HPV-3 | ML | |
| HPV-4 | F GRL Y | |
| HPV-16 | RVL | |
| HPV-18 | MCRL | |
| 304-319 | HPV-11 | F N K P Y W L Q K A Q G H N N |
| HPV-6b | ||
| HPV-1a | R SR CQ | |
| HPV-2a | R R | |
| HPV-3 | R R | |
| HPV-4 | RN RT | |
| HPV-16 | R | |
| HPV-18 | H | |
| 412-417 | HPV-11 | E D T Y R Y V Q S Q A I T C Q |
| HPV-6b | ||
| HPV-1a | QF L GS L A A K C | |
| HPV-2a | QL | |
| HPV-3 | F L TS | |
| HPV-4 | QF LRT RP | |
| HPV-16 | FTA | |
| HPV-18 | VFV |
a
The region of each peptide believed to lie within the HLA class II peptide binding groove is in boldface. GenBank accession numbers for the sequences of individual HPV types are as follows: HPV-11, NC_001525; HPV-6b, NC_001355; HPV-1, NC_001356; HPV-2, NC_001352; HPV-3, NC_001588; HPV-4, X70827; HPV-16, AF125673; HPV-18, NC_001357.