TABLE 1.
Plant | Mouse no. | MV-specific IgG titer
|
|||
---|---|---|---|---|---|
Preboost
|
Day 125 postboost | ||||
Day 0 | Day 42 | Day 70 | |||
MV-H | 1 | 0 | 64 | 77 | 730 |
2 | 0 | 90 | 3,250 | 10,000 | |
3 | 0 | 75 | 850 | 550 | |
4 | 0 | 280 | 80 | 730 | |
5 | 0 | 990 | 990 | 6,400 | |
6 | 0 | 820 | 820 | 460 | |
7 | 0 | 700 | 460 | 820 | |
Avg | 0 | 430 | 932 | 2,813 | |
Control | 1 | 0 | 460 | 75 | 77 |
2 | 0 | 325 | 800 | 280 | |
3 | 0 | 75 | 850 | 640 | |
4 | 0 | 35 | 700 | 730 | |
Avg | 0 | 223 | 606 | 432 |
All mice received a single, 50-μg, intramuscular dose of MV-H DNA on day 0, followed by four 1-g doses of plant extract with a mucosal adjuvant delivered orally by gavage on days 90, 97, 104, and 111.