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RBV does not induce mutations in nonreplicating HCV RNA
| Condition | Total no. of clones | No. (%) of mutant clones | Total no. of mutations (all regions) | Nonsynonymous/synonymous substitutions (ratio) | Error generation rate (10−3) (all regions) |
|---|---|---|---|---|---|
| Untreated T7/ΔBglII | 42 | 0 (0) | 0 | 0/0 | 0 |
| + RBV (50 μM) | 28 | 2 (6) | 2 | 1/1 (1.0) | 0.16a |
Not significantly different from the rate for untreated T7/ΔBglII.
