TABLE 5.
Comparison of mutation rates across all regions tested for untreated, RBV-treated, and IFN-treated replicating HCV RNA in CV-1 cells
| Condition | Total no. of clones | No. (%) of mutant clones | Total mutations (all regions) | Nonsynonymous/synonymous substitutions (ratio) | Error generation rate (10−3) (all regions) | Pa |
|---|---|---|---|---|---|---|
| T7/H77 (untreated) | 73 | 8 (11) | 14 | 8/6 (1.33) | 0.09 | |
| + RBV (50 μM) | 87 | 29 (33) | 55 | 40/15 (2.67) | 0.33 | <0.001 |
| + RBV (400 μM) | 85 | 25 (30) | 32 | 22/10 (2.2) | 0.20 | <0.008 |
| + IFN | 65 | 19 (30) | 30 | 20/10 (2.0) | 0.23 | <0.01 |
a
Significantly different from untreated T7/H77 by the χ2 test with Yates' correction.