Skip to main content
[Preprint]. 2026 Aug 11:rs.3.rs-10480838. [Version 1] doi: 10.21203/rs.3.rs-10480838/v1

Extended Data Fig. 8. Secondary principal components capture diagnosis-spanning meta-program variation.

Extended Data Fig. 8.

(a) Variance explained by each principal-component (PC) across diagnostic groups. Fill color denotes PC variance divided by total variance (× 100). (b) Variance explained by each PC at the diagnostic group level. Boxes show the median and IQR. (c) MP loading across principal components, with positive and negative coefficients shown in red and blue, respectively. (d, e) Top-ranked positive- and negative-pole enrichment terms for PC2 (d) and PC3 (e), respectively. Bar plot, absolute normalized enrichment score (|NES|); red and blue indicate positive and negative NES, respectively. Right-hand values are Benjamini–Hochberg false discovery rates (FDR); bolded labels denote FDR < 0.05.