Extended Data Fig. 9. C5 and NRCAM mark opposing poles of the injury–homeostatic CSF axis across cohorts and diagnoses.

(a, b) Study-level associations between NRCAM (a) or C5 (b) abundance and injury-homeostatic axis score. Spearman correlations were estimated within each cohort using sample-level abundance and Axis scores, then pooled using Fisher’s z random-effects meta-analysis. Inset shows Rho, 95% CI, FDR, k (studies), n (samples), and I². (c) NRCAM (blue) and C5 (red) expression across diagnostic groups. Data are mean standardized expression ± 95% CI for each protein; point size is proportionate to sample size, and connecting segments show the within-diagnosis NRCAM–C5 differences. (d) Diagnosis-level summaries of NRCAM and C5 abundance.