Extended Data Fig. 10. The injury–homeostatic meta-program axis organizes CSF proteomic states across diagnoses.

(a) Heatmap of mean GSVA activity for the 13 consensus CSF MPs across diagnoses from 35 cohorts. Rows, diagnosis groups rank-ordered by mean Axis score; columns, MPs rank-ordered by PC1 loading. (b) Sample-level association between cohort composition and mean Axis score. X-axis, proportion of non-control samples; point size, sample size; line, linear OLS fit with 95% CI. (c) Protein-set surrogate reconstruction of the axis using GSVA. Axis-positive and axis-negative protein sets were defined from the pooled protein–axis association (|ρ| ≥ 0.40 and FDR ≤ 0.05; Supplementary Tables 4 and 13). Each point represents one sample, plotted by axis-positive and axis-negative GSVA scores and coloured by the corresponding PC1-derived axis score. GSVA, gene set variation analysis; PC1, principal component 1