Extended Data Fig. 5. Overlap between core CSF proteome clusters and meta-programs.

(a) Euler diagram of the detectable CSF proteome, the 747-protein core CSF proteome (Tier A/B), and the union of the 13 consensus meta-program (MP1–MP13) protein sets. (b) UpSet plot of multi-membership intersections across the 6 core classes (CC1–CC6) and the 13 meta-programs. (c) Jaccard similarity between core tier and meta-programs (bottom) and tier composition of each meta-program (top). (d) Alluvial diagram linking the Core Class proteins to their resolved meta-program assignments. (e) Jaccard similarity between core classes (CC1–CC6) and meta-programs. Outlined cells mark reciprocal best matches.