Table 1.
Sample demographics by group.
|
PSEN1E280A Carriers N = 481 |
APOE3Ch- PSEN1E280A Carriers N = 71 |
p-value2 | Non-Carriers N = 431 |
APOE3Ch Carriers N = 291 |
p-value2 | |
|---|---|---|---|---|---|---|
| Age (years) | 39 (32, 45) | 49 (35, 53) | 0.10 | 40 (36, 44) | 43 (35, 50) | 0.3 |
| Female sex (n) | 30 (63%) | 2 (29%) | 0.12 | 26 (60%) | 15 (52%) | 0.5 |
| Education (years) | 11 (7, 13) | 11 (7, 11) | 0.2 | 12 (8, 15) | 11 (5, 13) | 0.034 |
| Cognitively impaired (n) | 17 (35%) | 2 (29%) | >0.9 | 0 (0%) | 0 (0%) | >0.9 |
| MMSE score | 27 (23, 29) | 27 (19, 28) | 0.7 | 28 (28, 29) | 28 (28, 29) | >0.9 |
| CERAD WLL delayed recall score | 7 (2, 8) | 5 (1, 8) | 0.5 | 8 (6, 9) | 7 (6, 8) | 0.3 |
| Naming score | 13 (12, 14) | 13 (12, 15) | 0.7 | 13 (12, 14) | 13 (11, 14) | 0.4 |
| TMTA time (s) | 45 (36, 85)† | 63 (39, 70)† | 0.8 | 40 (30, 50) | 49 (39, 62) | 0.016 |
| TMTB time (s) | 94 (55, 164)† | 108 (58, 258)† | 0.8 | 80 (51, 119)† | 107 (74, 151)† | 0.077 |
| Raven score | 10 (7, 10)† | 10 (8, 11) | 0.6 | 10 (8, 11) | 10 (9, 11) | 0.4 |
| SMC score | 12 (5, 24)† | 7 (4, 27) | 0.5 | 6 (2, 8)† | 5 (3, 9)† | 0.9 |
| GDS score | 1.0 (0, 3.5) | 1.0 (0, 1.0) | 0.2 | 0 (0, 2) | 2 (1, 4) | 0.002 |
1
Median (Q1, Q3); n / N (%)
2
Wilcoxon rank sum test; Pearson's χ2 test
†
Missing values in PSEN1E280A carriers for TMTA time (n=1), TMTB time (n=19), abstract reasoningscore (n=1) and subjective memory complaints score (n=1); in APOE3Ch + PSEN1E280A carriers forTMTA time (n=1) and TMTB time (n=3); in non-carriers for TMTB time (n=8) and subjective memorycomplaints score (n=1); and in APOE3Ch carriers for TMTB time (n=8) and subjective memorycomplaints score (n=5)