TABLE 2.
Survival of BALB/c mice following ocular challenge with various amounts of HSV-IL-2a
| Virus | No. of mice surviving/total (% surviving) after challenge with:
|
|||
|---|---|---|---|---|
| 2 × 104 PFU/eye | 2 × 105 PFU/eyeb | 2 × 106 PFU/eye | 2 × 107 PFU/eye | |
| HSV-IL-2 | 5/5 (100) | 54/60 (90) | 13/15 (87)c | 10/10 (100) |
| McKrae | 0/5 (0) | 4/45 (9) | 0/5 (0) | NDd |
| dLAT2903 | 0/5 (0) | 6/45 (13) | 0/5 (0) | ND |
| HSV-IL-2Re | ND | 0/10 (0) | ND | ND |
Mice were inoculated ocularly with various amounts of each virus, and survival was determined as described in Materials and Methods.
Data from three separate experiments were combined.
Data from two separate experiments were combined.
ND, not done.
Rescued virus.