FIG. 4.

Prevention of neuronal apoptosis by inhibition of HIV-1 replication in MDM. MDM cultures were maintained with and without AZT (1 μM, added 1 h prior to HIV inoculation) and analyzed for p24 output (A). Supernatants (harvested at day 19) from each experimental condition were applied to NT2.N-astrocyte cultures, which were analyzed 48 h later for neuronal apoptosis (B), as in Fig. 3. Data represent the average percent neuronal apoptosis ± standard error from two independent experiments. Comparisons of means were made by Student's t test.