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. Author manuscript; available in PMC: 2006 Feb 14.
Published in final edited form as: Nature. 2005 May 12;435(7039):220–223. doi: 10.1038/nature03523

Figure 3.

Figure 3

Histology of native insulin-positive mice. Histology showing marked insulitis of NOD mice with one or more copies of the insulin 1 or insulin 2 gene, with or without the mutated preproinsulin (B16:alanine) transgene. a, Insulin 1+/+, insulin 2-/-, transgene-, killed at 14 weeks, diabetic at 14 weeks. b, Insulin 1+/+, insulin 2-/-, transgene-, killed at 10.5 weeks, diabetic at 10.5 weeks. c, Insulin 1+/-, insulin 2-/-, transgene+, killed at 15 weeks, diabetic at 15 weeks. d, Insulin 1-/-, insulin 2+/+, transgene-, killed at 20 weeks, not diabetic. e, Insulin 1-/-, insulin 2+/+, transgene+, killed at 21 weeks, not diabetic. f, Insulin 1-/-, insulin 2+/-, transgene+, killed at 35 weeks, not diabetic.