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. Author manuscript; available in PMC: 2006 Feb 14.
Published in final edited form as: Nature. 2005 Aug 11;436(7052):845–847. doi: 10.1038/nature03864

Figure 3.

Figure 3

hangAE10 shows impaired heat-ethanol cross-tolerance. a. Heat-ethanol cross-tolerance: Control flies (w) and flies lacking octopamine (w,T□h) show normal cross-tolerance, while hangAE10 mutants (w,hang) and the double mutant (w,T□h,hang) display strongly reduced cross-tolerance. n=8–10 experiments, *p<0.0001.

b. Ethanol tolerance, while reduced in hangAE10 and T□h flies (significant difference with control not indicated in panel), is essentially absent in the T□h,hang double mutant flies. n=4–6 experiments, *p<0.001.

c, d. hangAE10 flies show increased sensitivity to paraquat. Panel c and d depict survival data obtained after 24 and 48 hours, respectively. n=5 experiments, *p<0.001.