FIG. 8.

Comparison of inoculation site disease scores for WT HSV-1 (NS) and gC/gE mutant virus NS-gCΔC3,gE339 at 5 × 10⁴ PFU in the presence or absence of antibody and C. C3 knockout mice were mock immunized (No Ab or C), or C-sufficient mice were passively immunized with pooled human IgG (HSV antibody) (Ab + C). Results are plotted as the mean cumulative disease score from days 3 to 7 ± standard errors of the means (error bars). The number of replicate experiments is shown above the bars. Differences between the effects of antibody and C on WT versus gC/gE mutant virus, P = 0.001.