TABLE 2.
Explanation-induced reactivation of MCMV following immunosuppressiona
| Organ | No. of organs positive for CMV/total no. tested (% positive)
|
|
|---|---|---|
| Mock-treated mice | CY-treated mice | |
| Infected eye | 18/22 (82) | 16/21 (76) |
| Contralateral eye | 0/10 (0) | 4/9 (44) |
| Salivary gland | 7/11 (64) | 7/10 (70) |
| Spleen | 6/11 (55) | 4/10 (40) |
| Lung | 0/11 (0) | 1/10 (10) |
a
Latently infected mice were given a 4-week regimen of cyclophosphamide or were mock treated. Organs from animals from each of these groups were explanted onto MEF monolayers and cocultivated for 60 days or until viral CPE was observed.