Table 4.
Risk factors associated with persistent HR-HPV infection after surgical treatment.
| Characteristics | Postop HR-HPV persistence (until 6 mon) | |||
|---|---|---|---|---|
| Negative (n = 693) | Positive (n = 210) | P-value | ||
| Age (years) | 40.0 [35.0, 47.0] | 46.0 [35.2, 58.0] | <0.001 | |
| Age (years) | ≤30 | 71 (77.2%) | 21 (22.8%) | <0.001 |
| 31–45 | 412 (83.4%) | 82 (16.6%) | ||
| ≥46 | 210 (66.2%) | 107 (33.8%) | ||
| Menopausal | Postmenopausal | 129 (60.0%) | 86 (40.0%) | <0.001 |
| Premenopausal | 564 (82.0%) | 124 (18.0%) | ||
| Number of pregnancies | <3 | 424 (77.7%) | 122 (22.3%) | 0.471 |
| ≥3 | 269 (75.4%) | 88 (24.6%) | ||
| Parity | <2 | 520 (77.2%) | 154 (22.8%) | 0.685 |
| ≥2 | 173 (75.5%) | 56 (24.5%) | ||
| Preoperative HPV type | Single | 516 (82.8%) | 107 (17.2%) | <0.001 |
| Multiple | 177 (63.2%) | 103 (36.8%) | ||
| Cervical cytology | NILM | 274 (79.0%) | 73 (21.0%) | 0.138 |
| ASCUS/AGC | 164 (77.0%) | 49 (23.0%) | ||
| LSIL | 102 (68.9%) | 46 (31.1%) | ||
| ASC-H | 66 (75.9%) | 21 (24.1%) | ||
| HSIL | 87 (80.6%) | 21 (19.4%) | ||
| Cervical transformation zone (CTZ) | I | 305 (82.7%) | 64 (17.3%) | <0.001 |
| II | 199 (80.9%) | 47 (19.1%) | ||
| III | 189 (65.6%) | 99 (34.4%) | ||
| Number of cervical quadrants involved | 0 | 82 (68.9%) | 37 (31.1%) | 0.178 |
| 1 | 447 (77.5%) | 130 (22.5%) | ||
| 2 | 112 (77.2%) | 33 (22.8%) | ||
| 3 | 26 (86.7%) | 4 (13.3%) | ||
| 4 | 26 (81.2%) | 6 (18.8%) | ||
| Endocervical involvement | Negative | 443 (79.4%) | 115 (20.6%) | 0.024 |
| Positive (CIN1) | 86 (76.8%) | 26 (23.2%) | ||
| Positive (CIN2-3) | 164 (70.4%) | 69 (29.6%) | ||
| Glandular involvement | Yes | 431 (78.5%) | 118 (21.5%) | 0.139 |
| No | 262 (74.0%) | 92 (26.0%) | ||
| Colposcopic pathology | Chronic cervicitis | 10 (76.9%) | 3 (23.1%) | 0.223 |
| CIN1 | 92 (71.3%) | 37 (28.7%) | ||
| CIN2 | 333 (75.9%) | 106 (24.1%) | ||
| CIN3 | 258 (80.1%) | 64 (19.9%) | ||
| Postoperative pathology | CIN2 | 343 (73.9%) | 121 (26.1%) | 0.116 |
| CIN3 | 347 (79.8%) | 88 (20.2%) | ||
| CIS/AIS | 3 (75.0%) | 1 (25.0%) | ||
| Surgical margin | Negative | 603 (78.8%) | 162 (21.2%) | 0.001 |
| Ectocervical margin | 32 (74.4%) | 11 (25.6%) | ||
| Endocervical margin | 46 (59.7%) | 31 (40.3%) | ||
| Basal margin | 12 (66.7%) | 6 (33.3%) | ||