Table 2.
Multivariable Cox regression analysis for disease-free survival and overall survival in the training cohort
| Characteristic | Disease-free survival | Overall survival | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| CEA level | ||||
| Normal | Ref | Ref | ||
| Elevated | 1.505 (1.062–2.134) | 0.022 | 1.621 (1.105–2.377) | 0.013 |
| Depth of invasion | ||||
| pT1-2 | Ref | Ref | ||
| pT3 | 2.994 (1.537–5.831) | 0.001 | 2.858 (1.372–5.954) | 0.044 |
| pT4 | 3.900 (1.875–8.113) | < 0.001 | 4.145 (1.854–9.266) | 0.011 |
| Lymph node metastasis | ||||
| pN0 | Ref | Ref | ||
| pN1 | 2.228 (1.445–3.434) | 0.002 | 2.344 (1.450–3.789) | 0.001 |
| pN2 | 2.812 (1.788–4.423) | < 0.001 | 3.083 (1.887–5.038) | < 0.001 |
| TSP | ||||
| Low | Ref | Ref | ||
| High | 2.765 (1.931–3.961) | < 0.001 | 2.579 (1.744–3.813) | < 0.001 |
| P-TLS | ||||
| Low density | Ref | Ref | ||
| High density | 0.356 (0.232–0.546) | < 0.001 | 0.366 (0.229–0.588) | < 0.001 |
Abbreviations: HR hazard ratio, CI confidence interval, Ref reference, CEA carcinoembryonic antigen, TSP tumor stroma percentage, P-TLS peritumoral tertiary lymphoid structures
DFS model: likelihood ratio test: χ²= 97.373, P < 0.001
OS model: likelihood ratio test: χ²= 83.474, P < 0.001