Figure 3.

Perfusion density of the intermediate capillary plexus is lower in T2DM. Fovea-centered OCTA (10° × 10°) with enhanced depth imaging was acquired for all of the participants using the SPECTRALIS HRA2. The en face angiograms of each capillary plexus were extracted as .tif files. Images were then binarized and the PD of each plexus within the central 2-mm region was measured using a custom MATLAB program after correction for retinal magnification. The examiner was masked to the participant groups during analysis. Poor-quality images were excluded from analysis. Numbers on the plots represent the adjusted P values. Adjusted P < 0.05 was considered statistically significant. Healthy controls: HbA1c ≤ 5.6% (n = 17); PreDM: HbA1c = 5.7%–6.4% (n = 10); T2DM: HbA1c ≥ 6.5% (n = 13).