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. 2002 Oct;76(19):9763–9772. doi: 10.1128/JVI.76.19.9763-9772.2002

FIG. 3.

FIG. 3.

Effect of mitogenic pathways on a pX-dependent Stat3 activation. (A) Transient transfections were carried out for pLucTKS3 reporter (100 ng) in the presence of cotransfected plasmid encoding cytomegalovirus (CMV) empty vector (400 ng), dn Stat3S727A (400 ng), or dn JNK− (400 ng) where indicated. Inhibitor concentration is as follows: 3 μM PP2 (43, 44), 20 μM BAPTA-AM (7), 25 μM PD 98059 (24), and 10 μM SB 203580 (40). (B) Transient transfections of pLucTKS3 (100 ng) ± 5 μg of tetracycline/ml in clonal cell lines 4pX-1, 4pX-2, and 4pX-3 (54) in the presence of cotransfected Stat3S727A (400 ng) or 3 μM PP2 inhibitor.