FIG. 2.

Comparison of the polymerase active-site regions. (a) RT+M184V, RTMQ+M184V, RTMN, and RTMF-nevirapine are shown overlapped onto the wild-type RT-nevirapine complex. The main chain, side chains, and the inhibitor of wild-type RT are shown in orange and red, and those of mutant RTs are shown in blue and green. (b) RTMF-nevirapine, RTMF-1051U91, RTMN, and RTMQ+M184V are superimposed onto RTMC. The main chain, side chains, and the inhibitor of RTMC are colored in orange and red, those of RTMF-1051U91 are all in gray, and those of other mutant RTs are in blue and green, respectively.