TABLE 3.
SIV RNA expression in the LNs of i.v. infected macaques at 14 days p.i.
Animal | Inoculum (TCID50, i.v.)a | No. of RNA-positive cells perb:
|
|
---|---|---|---|
Section | mm2 | ||
AT 88 | 1 × 102, wt | 348.5 | 52 |
AR 80 | 1 × 102, wt | 234.5 | 16.1 |
AT 62 | 2.35 × 104, delta | 17.25 | 3.15 |
AT 84 | 2.35 × 104, delta | 8.2 | 0.4 |
AR 83 | 2.35 × 104, delta | 15 | 0.72 |
AR 85 | 2.35 × 104, delta | 132 | 6.5 |
wt, wild-type virus; delta, delta nef virus.
Average numbers of RNA-positive cells (by ISH) at day 14. LNs were biopsied at days 2, 5, 7, and 14. However, negligible numbers of SIV-positive cells were detected before day 14 (ranging from 0.08 to 2.25 SIV-positive cells per mm2 or 0.5 to 38 SIV-positive cells per section at day 7).