Table II.

Subdomains included in asthma remission definitions in studies explicitly assessing remission

Study	Time	Number of subdomains	No medications			No exacerbation	Absence of symptoms	Normal lung function	Other	% Achieving remission
			No OCS	No ICS	No rescue medication
Pumputiene et al (2006)24	12 mo	2					×	× ∗FEV1 ≥80%		NR
Manuyakorn et al (2008)25	12 mo	3		×			×	× FEV1 > 80% and FEV1/FVC > 80%		NR
Covar et al (2011)26	12 mo	3	×	×	×	×	×			4
Andersson et al (2013)30	36 mo	2	×	×	×		× Absence of wheezing			10
Odajima et al (2017)23	NR	1					× JPAC = 15/15			40
Longo et al (2021)21	24 mo	3	×	×	×	×			× Absence of hospitalization or physician visit for asthma	41.5
Bacharier et al (2024)22	12m	4	×				× ACQ5 < 0.75	× z Score > -1.64 for FEV1 and FEV1/FVC		41.9 for children receiving dupilumab; 23.7 in the placebo group

The “×” symbol indicates that the absence of the domain was explicitly required as part of the remission definition for the specified duration. Blank cells indicate that the domain was not included in the study’s remission definition. DeBoer et al²⁸ were excluded from this table because no explicit definition of asthma remission was provided. Notably, no study incorporated biologic or inflammatory markers as part of their remission definitions.

ACQ-5, Asthma Control Questionnaire 5; FVC, forced vital capacity; ICS, Inhaled corticosteroids; JPAC, Japanese Pediatric Asthma Control questionnaire; NR, not reported; OCS, oral corticosteroids.