TABLE 1.
Patient no. | Age (yr) | HIV subtypea | Time virus undetectable before STI (mo) | Before ART
|
Baseline of STI trial
|
Wk 52 HIV RNA (copies/ml) | ||
---|---|---|---|---|---|---|---|---|
Plasma HIV RNA (copies/ml) | CD4 cell count (cells/mm3) | CD4 cell count (cells/mm3) | ARTd | |||||
1 | 41 | B | 32 | 561,831 | 280 | 723 | ZDV-3TC-IDV | —e |
2 | 52 | B | 26 | 128,555c | 794 | 1,269 | ZDV-3TC-IDV | 41,316 |
3 | 38 | B | 31 | 34,752 | 1,010 | 1,115 | ZDV-3TC-RTV | — |
4 | 38 | B | 11 | 122,902c | 259 | 422 | DDI-D4T-NFV | 19,127 |
5 | 46 | B | 25 | 32,608c | 388 | 347 | ZDV-3TC-IDV | 8,757 |
6 | 53 | B | 32 | 467,593 | 11 | 350 | ZDV-3TC-IDV | — |
7 | 33 | B | 30 | 16,927 | 573 | 832 | ZDV-3TC-IDV | 4,560 |
8 | 55 | B | 28 | 162,701c | 461 | 766 | ZDV-3TC-IDV | 21,848 |
9 | 38 | B | 12 | 164,772 | 272 | 591 | D4T-3TC-NFV | 51,008 |
10 | 35 | E/CRF1b | 23 | 11,298 | 495 | 777 | DDI-D4T-NFV | 3,466 |
11 | 52 | B | 22 | 25,417 | 302 | 839 | D4T-3TC-NFV | 189,929 |
12 | 43 | B | 25 | 9,404 | 327 | 749 | ZDV-DDI-NFV | 24,587 |
13 | 68 | A | 31 | 821c | 650 | 670 | ZDV-3TC-NFV | 286 |
Mean (range) | 46 (33-68) | 25 (11-32) | 133,814 (821-561,831) | 448 (11-1,010) | 739 (347-1,269) | 36,488 (286-189,929) |
Determined as described previously (39).
CRF1, circulating recombinant form 1.
Geometric mean, because two pretreatment HIV RNA values were available before initiation of ART.
ZDV, zidovudine; 3TC, lamivudine; IDV, indinavir; DDI, didanosine; RTV, ritonavir; D4T, stavudine; NFV, nelvinafir.
—, treatment had to be reinitiated between weeks 40 and 52.