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. 2002 Oct;76(20):10169–10176. doi: 10.1128/JVI.76.20.10169-10176.2002

TABLE 2.

Doubling times of plasma HIV RNA during STIs and first- and second-phase decay half-lifes after resumption of treatment

Patient no. VL (copies/ml)
Doubling time (days) during STI:
First-phase decay half-life (days) after STI:
Second-phase decay half-life (days) after STI:
Pretreatment Plateau 1 2 3 4 5 1 2 3 4 1 2 3 4
1 561,831 76,805 1.18 1.24 1.15 2.10 1.49 1.48 1.42 1.52 NAa 15.53 18.85 27.31 15.11
2 80,600 21,393 NA NA NA NA 1.33 NA NA NA NA NA NA NA NA
3 34,752 115,546 0.78 1.31 1.26 1.33 1.33 3.06 1.98 2.26 1.77 16.32 16.35 10.57 15.19
4 122,729 19,344 1.04 1.21 1.25 1.29 1.35 2.26 1.23 2.21 1.93 12.06 8.80 10.05 11.14
5 32,140 6,459 10.26 4.89 1.52 1.13 3.56 2.10 1.42 1.49 1.78 NA NA 18.19 14.01
6 467,598 31,500 1.06 0.85 1.28 1.38 1.25 1.61 1.18 1.59 1.26 13.12 10.92 14.83 10.65
7 16,927 3,140 0.95 1.01 1.99 1.21 1.48 1.16 1.94 NA 1.07 1,664.09 6.05 NA 14.08
8 150,390 40,176 3.67 1.74 8.00 3.31 1.35 5.63 2.05 14.27 1.88 32.94 −95.31 11.20 NA
9 164,772 65,941 1.38 1.46 3.18 2.36 1.78 1.94 1.02 17.69 NA 9.70 18.88 12.40 11.76
10 11,298 4,623 1.97 7.86 3.67 1.26 3.58 2.00 2.13 1.38 1.24 −48.28 NA NA NA
11 25,417 106,928 2.01 2.15 2.73 2.46 3.16 2.22 8.48 1.98 3.54 −72.05 19.87 −20.33 −57.25
12 9,404 20,236 1.00 1.25 0.99 2.86 7.65 1.17 1.37 NA 1.88 14.87 13.17 21.65 21.15
13 537 105 NA NA NA NA 1.86 NA NA NA NA NA NA NA NA
Mean 2.30 2.27 2.46 1.88 2.40 2.24 2.20 4.93 1.82 165.83 1.96 11.76 6.20
a

NA, not available (either no rebound was observed during the 2-week STI or not enough data points were available to calculate first- and second-phase half-lives).