Table 4. Multivariable Cox proportional-hazard regression analysis for overall survival.

Variable		Univariable analysis		Multivariable analysis
		HR (95% CI)	P	HR (95% CI)	P
Main variable
	TARE (vs. TACE)	0.580 (0.401–0.840 )	0.004	0.624 (0.422–0.924)	0.018
Adjustment variables
	Sex, man	1.540 (0.953–2.489)	0.078	1.447 (0.883–2.372)	0.142
	Age >70 years	2.221 (1.610–3.063)	<0.001	2.697 (1.867–3.896)	<0.001
	Tumor size >8 cm	1.684 (1.195–2.371)	0.003	1.460 (0.965–2.210)	0.074
	Albumin <4.0 g/dL	1.799 (1.273–2.542)	<0.001
	Total bilirubin >1.2 mg/dL	1.187 (0.749–1.880)	0.466
	PT INR >1.1	1.297 (0.875–1.922)	0.195
	Child–Pugh class A6/B7	1.436 (1.000–2.063)	0.050
	ALBI grade 2	1.571 (1.150–2.147)	0.005	1.259 (0.913–1.736)	0.161
	AST >40 IU/L	1.352 (0.979–1.867)	0.067	1.192 (0.806–1.765)	0.379
	ALT >40 IU/L	1.195 (0.869–1.645)	0.273
	Creatinine >1.2 mg/dL	2.372 (1.599–3.519)	<0.001	1.825 (1.176–2.834)	0.007
	AFP >200 ng/mL	1.742 (1.271–2.389)	<0.001	2.108 (1.497–2.970)	<0.001
	PIVKA >200 mAU/mL	1.535 (1.000–2.355)	0.050	1.601 (1.008–2.541)	0.046
	Platelet <130 ×103/µL	1.160 (0.762–1.767)	0.489
	HBV	1.036 (0.742–1.447)	0.833
	HCV	0.866 (0.382–1.962)	0.731
	Alcohol	0.756 (0.504–1.133)	0.175

HR = hazard ratio, CI = confidence interval, TARE = transarterial radioembolization, TACE = transarterial chemoembolization, PT = prothrombin time, INR = international normalized ratio, ALBI = albumin bilirubin, AST = aspartate aminotransferase, ALT = alanine aminotransferase, AFP = alpha-fetoprotein, PIVKA = protein induced by vitamin K absence, HBV = hepatitis B virus, HCV = hepatitis C virus