TABLE 1.

Magnitude and density of HIV-1C-specific CTL responses^a

Protein	No. of synthetic peptides	Magnitude of response (SFC/106 PBMC)			Density of responseb	Frequency of high CTL responses (%)c	No. (%d) of nonresponsive peptides
		Mean ± SD	Median	Range
Gag p17	13	258 ± 143	200	100-556	0.046	5.7	1 (7.7)
Gag p24	24	388 ± 270	300	100-1,447	0.078	23.4	0
Gag p2/p7/p1/p6	14	292 ± 162	271	100-786	0.046	10.5	2 (14.3)
Pol protease	13	163 ± 67	135	107-338	0.040	0	1 (7.7)
Pol RT	44	226 ± 192	168	100-1,195	0.031	5.3	17 (38.6)
Pol RNase H	17	214 ± 110	210	102-438	0.010	0	9 (52.9)
Pol integrase	38	227 ± 106	190	108-672	0.025	1.6	18 (47.4)
Vif	18	223 ± 122	187	104-817	0.048	2.1	1 (5.6)
Vpr	9	196 ± 73	196	101-403	0.067	0	0
Tat	18	249 ± 115	218	117-667	0.061	6.6	5 (27.8)
Rev	19	244 ± 143	220	100-1,074	0.049	2.0	0
Vpu	11	142 ± 51	122	100-269	0.030	0	2 (18.2)
Env gp120	52	180 ± 115	146	100-916	0.023	2.7	18 (34.6)
Env gp41	34	213 ± 117	179	101-769	0.041	3.8	6 (17.6)
Nef	30	278 ± 152	241	100-1,057	0.085	7.2	0

^aThe magnitudes and densities were computed using samples with a positive response only.

^bDensity was computed as the number of CTL responses higher than 100 SFC/10⁶ PBMC within the protein normalized by the number of peptides used and the number of samples tested [density = number of CTL responses/(number of peptides × number of samples)].

^cPercentage of responses that were equal to or higher than 500 SFC/10⁶ PBMC out of the total number of responses within a particular viral protein.

^dPercentage of peptides with no responses out of the total number of synthetic peptides within a particular viral protein.