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Temperature sensitivity and neurovirulence of virus 31043
| Virus | Log titer reduction
|
Neurovirulence in TgPVR21 mice
|
|||
|---|---|---|---|---|---|
| 35-39.5°C | 35-40.0°C | Dose (log CCID50/ml) | No. of clinically affected mice/total no. | PD50a | |
| Sabin 3 | 3.4 | >5.0 | 7.7 | 0/12 | >7.7 |
| 31043 | 0.5 | 2.0 | 8.0 | 9/10 | 7.3 (7.1-7.6) |
| 7.5 | 6/10 | ||||
| 6.5 | 3/10 | ||||
| 5.5 | 0/10 | ||||
| Leon | 0.2 | 0.5 | 6.5 | 6/6 | 5.7 (5.3-6.4) |
| 5.5 | 2/6 | ||||
| 4.5 | 1/6 | ||||
| 3.5 | 0/6 | ||||
Estimates of the PD50 with associated 95% confidence intervals were calculated by the probit method.
