TABLE 1.
Selection of mutants resistant to the neutralization by p75-Fc
| Name of mutant | Parent virus | Titer
|
Plating efficiencya | |
|---|---|---|---|---|
| − anti-Fc Ab | p75-Fc + anti-Fc Ab | |||
| 2-4 | CVS-2 | 5 × 107 | 5 × 107 | 1 |
| 4-1 | CVS-4 | 7.5 × 107 | 5 × 107 | 0.7 |
| 5-4 | CVS-5 | 1 × 107 | 1 × 107 | 1 |
| 6-5 | CVS-6 | 5.5 × 107 | 7 × 107 | 1.3 |
| 7-5 | CVS-7 | 4.7 × 107 | 8.3 × 107 | 1.8 |
| 8-2 | CVS-8 | 5 × 107 | 6.5 × 107 | 1.3 |
| 9-1 | CVS-9 | 2.3 × 107 | 4 × 107 | 1.7 |
| 10-5 | CVS-10 | 1.5 × 107 | 1.5 × 107 | 1 |
a
The plating efficiency of the mutants was determined by dividing the titer obtained in presence of p75-Fc by the titer obtained in its absence.