TABLE 2.

Characterization of eight independent mutants resistant to neutralization by p75-Fc^a

Name of mutant	Plaque phenotype	Mutation in glycoprotein gene
		Amino acid no.	Nature of substitution	Change in codon
2-4	small	352	H to R	CAT to CGT
4-1	small	352	H to R	CAT to CGT
5-4∗	large	318	F to V	TTC to GTC
6-5∗	small	318	F to S	TTC to TCC
7-5∗	large	352	H to Y	CAT to TAT
8-2	large	318	F to V	TTC to GTC
9-1∗	small	352	H to R	CAT to CGT
10-5	small	318	F to S	TTC to TCC

^aOne mutant per CVS stock was amplified and analyzed for the plaque phenotype on BSR cells. The entire gene of the glycoprotein was sequenced for the mutants noted by an asterisk, and partial sequence (amino acids 254 to 429) was obtained for the others.