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. 2026 Sep 30;13:1909444. doi: 10.3389/fmed.2026.1909444

Figure 2.

Panel A shows a dot plot of gene ontology enrichment, with gene ratios on the x-axis and gene sets on the y-axis, indicating p-values by color and count by dot size. Panel B displays a dot plot of pathway enrichment, with gene ratios and pathway names, where p-values are color-coded and gene counts represented by dot size. Panel C provides a network diagram illustrating protein-protein interactions among labeled genes or proteins, connected by colored lines indicating functional associations.

Functional enrichment and protein-protein interaction analyses of candidate genes. (A) Gene Ontology (GO) enrichment analysis of the 17 candidate genes, including biological process, cellular component, and molecular function categories. (B) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the candidate genes. (C) Protein-protein interaction (PPI) network of candidate genes constructed using the STRING database with a minimum interaction score >0.15. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; PPI, protein-protein interaction.