Abbreviation	Definition
PSC	Primary sclerosing cholangitis
PSC-UC	Primary sclerosing cholangitis-associated ulcerative colitis
UC	Ulcerative colitis
miRNA	microRNA
PI3K	Phosphoinositide 3-kinase
AKT	Protein kinase B
STAT3	Signal transducer and activator of transcription 3
NF-κB	Nuclear factor kappa B
PDCD4	Programmed cell death protein 4
CYLD	CYLD lysine 63 deubiquitinase
PCA	Principal component analysis
ROC	Receiver operating characteristic
AUC	Area under the curve
GLM	General linear model
PBS	Phosphate-buffered saline
SEM	Standard error of the mean
ANOVA	Analysis of variance
kNN	k-nearest neighbours