FIG. 4.

The BZLF1 and BRLF1 adenoviruses induce cellular necrosis and apoptosis in C18 NPC tumors. GFP, BZLF1, or BRLF1 adenovirus was injected directly into C18 NPC tumors established in nude mice. Two days later, mice were euthanized and tumors were dissected and fixed. Sections of tumors, treated with GFP adenovirus (A and D), BZLF1 adenovirus (B and E), or BRLF1 adenovirus (C and F), were stained with hematoxylin and eosin (A, B, and C) (magnification, ×400) or TUNEL (D, E, and F) (magnification, ×200).