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. 2026 Oct 1;18(19):3172. doi: 10.3390/cancers18193172
AE Adverse event
AJCC American Joint Committee on Cancer
CI Confidence interval
CR Complete response
CTCAE Common Terminology Criteria for Adverse Events
CTLA-4 Cytotoxic T-lymphocyte–associated protein 4
DEC-C Decitabine/cedazuridine
DLT Dose-limiting toxicity
DNA Deoxyribonucleic acid
DNMT1 DNA methyltransferase 1
ECOG Eastern Cooperative Oncology Group
EOT End of treatment
FDA United States Food and Drug Administration
GAPDH Glyceraldehyde-3-phosphate dehydrogenase
gDNA Genomic DNA
GZMB Granzyme B
HMA Hypomethylating agent
ICI Immune checkpoint inhibitor
IFI6 Interferon alpha-inducible protein 6
IFI27 Interferon alpha-inducible protein 27
IFI44L Interferon-induced protein 44-like
IFN Interferon
IIPS Innate immune pathogen-sensing
IL Interleukin
IQR Interquartile range
LAG-3 Lymphocyte-activation gene 3
LDH Lactate dehydrogenase
LINE-1 Long interspersed nuclear element-1
M:U Methylated-to-unmethylated
MDSC Myeloid-derived suppressor cell
MHC Major histocompatibility complex
MTD Maximum tolerated dose
NCCN National Comprehensive Cancer Network
NK Natural killer
NKG2D Natural killer group 2 member D
NR Not reached
ORR Objective response rate
OS Overall survival
PBMC Peripheral blood mononuclear cell
PD Progressive disease
PD-1 Programmed death-1
PFS Progression-free survival
PR Partial response
qRT-PCR Quantitative real-time polymerase chain reaction
RECIST Response Evaluation Criteria in Solid Tumors
RIG-I Retinoic acid-inducible gene-I
RNA Ribonucleic acid
RP2D Recommended phase II dose
SAE Serious adverse event
SD Stable disease
SEM Standard error of the mean
TIM-3 T-cell immunoglobulin and mucin-domain containing-3
TITE-BOIN Time-to-event Bayesian optimal interval
TNF-α Tumor necrosis factor-alpha
Treg Regulatory T cell
ULN Upper limit of normal