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. 2002 Nov;76(21):10702–10707. doi: 10.1128/JVI.76.21.10702-10707.2002

FIG. 2.

FIG. 2.

IL-18 inhibits HBV replication: time course. Age-, sex-, and serum HBeAg-matched lineage 1.3.32 HBV transgenic mice were injected subcutaneously with a single dose (10 μg) of IL-18 and sacrificed at the indicated time points. Total hepatic DNA was analyzed for HBV DNA by Southern blot analysis. The mean sALT activity, measured at the time of autopsy, is indicated for each group and is expressed in units/liter. Total hepatic RNA from the same mice was also analyzed by RPA for the expression of various cytokines as indicated. The RNA encoding the ribosomal protein L32 was used to normalize the amount of RNA loaded in each lane. Results were compared with those observed in livers from two age-, sex-, and serum HBeAg-matched transgenic littermates injected with saline (NaCl).