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. 2026 Sep 29;18(19):3159. doi: 10.3390/cancers18193159
ADC Antibody-Drug Conjugate
AI Artificial Intelligence
AKI Aurora Kinase Inhibitor
AI/ML Artificial Intelligence / Machine Learning
ASCL1 Achaete-Scute Family BHLH Transcription Factor 1
AUC Area Under the Receiver Operating Characteristic Curve
BCL2 B-Cell Lymphoma 2
BiTE Bispecific T-Cell Engager
BTK Bruton Tyrosine Kinase
CHK1 Checkpoint Kinase 1
C-Index Concordance Index
CT Computed Tomography
cfDNA Circulating-Free DNA
ctDNA Circulating-Tumor DNA
DNA Deoxyribonucleic Acid
EGFR Epidermal Growth Factor Receptor
FDA Food and Drug Administration
GBM Gradient Boosting Machine
GPCR G Protein-Coupled Receptor
HER2 Human Epidermal Growth Factor Receptor 2
HR Hazard Ratio
ISG+ Interferon-Stimulated Gene-Positive
KDR Kinase Insert Domain Receptor (VEGFR2)
KNN K_Nearest Neighbors
LDCT Low-Dose Computed Tomography
LUAD Lung Adenocarcinoma
ML Machine Learning
MLP Multilayer Perceptron
MET Mesenchymal-Epithelial Transition Factor
MHC Major Histocompatibility Complex
MYC MYC Proto-Oncogene, BHLH Transcription Factor
NCAM1 Neural Cell Adhesion Molecule 1
NE Neuroendocrine
NEUROD1 Neuronal Differentiation 1
NLST National Lung Screening Trial
NMF Non-Negative Matrix Factorization
NSCLC Non-Small Cell Lung Cancer
OS Overall Survival
PARP Poly (ADP-Ribose) Polymerase
PFS Progression Free Survival
PD-1 Programmed Cell Death Protein 1
PD-L1 Programmed Death Ligand 1
POU2F3 POU Class 2 Homeobox 3
RB1 Retinoblastoma 1
RF Random Forest
RNA Ribonucleic Acid
Rucaparib Poly ADP-Ribose Polymerase Inhibitor (drug)
SCLC Small-Cell Lung Cancer
SCLC-A ASCL1-Driven SCLC Subtype
SCLC-N NEUROD1-Driven SCLC Subtype
SCLC-P POU2F3-Driven SCLC Subtype
SCLC-I Immune-Inflamed SCLC Subtype
SEPA Signaling Entropy for Survival Analysis
SOX2 SRY-Box Transcription Factor 2
STK11 Serine/Threonine Kinase 11
Sybil Deep-Learning Lung Cancer Risk Prediction Model
TET2 Tet Methylcytosine Dioxygenase 2
TF Transcription Factor
TIME Tumor Immune Microenvironment
TKI Tyrosine Kinase Inhibitor
TME Tumor Microenvironment
TP53 Tumor Protein P53
T-SCLC Transformed Small-Cell Lung Cancer
XGBoost Extreme Gradient Boosting