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. 2026 Oct 14;3(1):e20260040. doi: 10.70962/jhi.20260040

Figure 6.

Multiple graphs depict changes in quality of life over time. Panel A: Vertical bar graphs comparing baseline and latest timepoint scores for various health-related quality of life (QoL) subscales and components from the SF-36 survey. The y-axis represents the mean score, and the x-axis lists different subscales and components. Panel B: Bar graphs showing the percentage of patients with clinically relevant changes in SF-36 scores, divided into all patients and those with low QoL at baseline. The y-axis represents the percentage of patients, and the x-axis lists different subscales and components. Panel C: Bar graph comparing mean patient global assessment (PtGA) scores at baseline and the latest timepoint, with the y-axis representing the PtGA VAS score in millimeters. Panel D: Box plot for mean physician global assessment (PGA) scores. The graphs illustrate improvements in QoL and reductions in disease activity over time.

Changes in QoL over time. (A) Normed subscale and component scores from the SF-36 survey, with higher scores indicating greater health-related QoL. Differences in scores between baseline and the latest time point that meet or exceed MIDs are illustrated with a delta symbol (Δ) followed by the value of the difference. The dotted line indicates the general US population average. (B) All patients and patients with low SF-36 scores (<45) at baseline with clinically relevant changes in SF-36 scores at their last visit. The bottom table shows responder analysis of patients with low SF-36 scores at baseline. (C and D) (C) Mean patient and (D) physician global assessment scores are shown, with lower scores indicating a reduction in disease activity. n values in C and D are 37 and 32, respectively. Baseline was defined as the start of either the DFT or RCT. If a patient had a treatment gap >42 days between the DFT or RCT and the OLE, or they did not participate in either trial. ED 1 values were used as baseline. Error bars are SD. BP, bodily pain; CFB, change from baseline; GH, general health; MH, mental health; MID, minimally important difference; PF, physical functioning; PGA, physician global assessment; PtGA, patient global assessment; QoL, quality of life; RCT, randomized controlled trial; RE, role (emotional); RP, role (physical); SF, social functioning; VT, vitality.