Table 3.
Brain Regions Displaying Significant Changes in Measured Activity for the Contrast "Location — Detection"
| Peak MNI |
|||||
|---|---|---|---|---|---|
| Brain Region | Z score | Volume (mm3) | X | Y | Z |
| Control Subjects | |||||
| Parietal lobe | |||||
| Postcentral gyrus (R) | 4.44 | 972 | 51 | -27 | 48 |
| Postcentral gyrus (L) | 4.02 | 1566 | -48 | -33 | 51 |
| Superior parietal gyrus (L) | 3.46 | 648 | -15 | -75 | 57 |
| Occipital Lobe | |||||
| Lingual gyrus (bilateral) | 4.13 | 9693 | -6 | -96 | -3 |
| IFN-α | |||||
| Frontal lobe | |||||
| Superior frontal sulcus (L) | 4.43 | 1863 | -27 | 0 | 60 |
| Inferior frontal gyrus (L) | 4.15 | 405 | -51 | 21 | -12 |
| Anterior cingulate (BA24) (L) | 3.47 | 270 | -3 | -3 | 51 |
| Parietal lobe | |||||
| Superior parietal gyrus (R) | 4.04 | 4023 | 15 | -72 | 54 |
| Superior parietal gyrus (L) | 3.80 | 1728 | -9 | -63 | 63 |
| Postcentral gyrus (L) | 3.90 | 405 | -30 | -39 | 69 |
| Postcentral gyrus (R) | 3.72 | 1107 | 45 | -33 | 48 |
| Occipital lobe | |||||
| Lingual gyrus (bilateral) | 5.22 | 9963 | -9 | -99 | -3 |
| Control Subjects > IFN-α | |||||
| None | |||||
| IFN-α > Control Subjects | |||||
| Frontal lobe | |||||
| Anterior cingulate (BA24) (L) | 4.37 | 324 | 0 | 0 | 48 |
Statistical threshold was set at p <.001, uncorrected, limited to clusters of volume ≥270 mm3 (≥10 voxels). MNI, Montreal Neurological Institute; R, right; L, left; IFN, interferon; BA, Brodmann's area.