2′-MOE	2′-O-methoxyethyl
AAV	Adeno-associated virus
AAV9	Adeno-associated virus serotype 9
ACE	Angiotensin-converting enzyme
AH50	50% alternative pathway haemolytic activity
ALT	Alanine aminotransferase
AP	Alternative pathway
APRIL	A proliferation-inducing ligand
ARB	Angiotensin-receptor blocker
AST	Aspartate aminotransferase
Ba, Bb	Activation fragments of complement factor B
BAFF	B-cell activating factor
C1GalT1	Core 1 β1,3-galactosyltransferase (protein)
C3	Complement component 3
C3b	Activated fragment of complement component 3
C5	Complement component 5
C5a	Anaphylatoxin fragment of complement component 5
CD4	Cluster of differentiation 4
CFHR3,1Δ	84 kb deletion encompassing CFHR3 and CFHR1
CH50	50% total haemolytic complement activity
CKD	Chronic kidney disease
Cosmc	Core 1 β3-Gal-T-specific molecular chaperone
CRISPR-Cas	Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein
DNA	Deoxyribonucleic acid
eGFR	Estimated glomerular filtration rate
EMA	European Medicines Agency
ERA	Endothelin type A receptor antagonist
FDA	US Food and Drug Administration
FH	Complement factor H (protein)
GalNAc	N-acetylgalactosamine
GBM	Glomerular basement membrane
Gd-IgA1	Galactose-deficient IgA1
GWAS	Genome-wide association study
HLA	Human leukocyte antigen
IgA	Immunoglobulin A
IgA1	Immunoglobulin A1
IgAN	IgA nephropathy
IgG	Immunoglobulin G
IL-6	Interleukin 6
IL-18	Interleukin 18
IND	Investigational New Drug
IV	Intravenous
kDa	Kilodalton
KDIGO	Kidney Disease: Improving Global Outcomes
let-7b	Lethal-7b microRNA
MAC	Membrane attack complex
MAPK/ERK1/2	Mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2
MHC	Major histocompatibility complex
miR-148b	MicroRNA-148b
miRNA	MicroRNA
mRNA	Messenger RNA
MZ	Monozygotic
NF-κB	Nuclear factor κB
rAAV	Recombinant adeno-associated virus
RAS	Renin–angiotensin system
REMS	Risk Evaluation and Mitigation Strategy
RNA	Ribonucleic acid
RP	Renal pelvis
RV	Renal vein
s.c.	Subcutaneous
SGLT-2	Sodium–glucose co-transporter 2
siRNA	Small interfering RNA
SNP	Single-nucleotide polymorphism
ST6GalNAc-II	ST6 N-acetylgalactosaminide α-2,6-sialyltransferase 2 (protein)
ssDNA	Single-stranded DNA
TACI	Transmembrane activator and CAML interactor
tRNA	Transfer RNA
UPCR	Urine protein-to-creatinine ratio
UTR	Untranslated region
Gene symbols
ANKRD16	Ankyrin repeat domain 16
C1GALT1	Core 1 β1,3-galactosyltransferase 1
C1GALT1C1	C1GALT1-specific chaperone 1
CCR6	C-C motif chemokine receptor 6
CFB	Complement factor B
CFH	Complement factor H
CFHR1, CFHR3	Complement factor H-related protein 1, 3
CFI	Complement factor I
COL4A3, COL4A4, COL4A5	Collagen type IV α3, α4, α5 chain
DEFA	α-defensin
FBXL21	F-box and leucine-rich repeat protein 21
GALNT2, GALNT12	Polypeptide N-acetylgalactosaminyltransferase 2, 12
IL1A, IL1B, IL1RN, IL10	Interleukin 1α, interleukin 1β, interleukin 1 receptor antagonist, interleukin 10
LYN	LYN proto-oncogene, Src-family tyrosine kinase
LIF	Leukaemia inhibitory factor
OSM	oncostatin M
PKD1L3	polycystin 1-like 3
REL, RELA	REL proto-oncogene/RELA proto-oncogene, NF-κB subunit
SPRY2	Sprouty RTK signalling antagonist 2
ST6GAL1	β-galactoside α-2,6-sialyltransferase 1
ST6GALNAC2	ST6 N-acetylgalactosaminide α-2,6-sialyltransferase 2
STAT3	Signal transducer and activator of transcription 3
TLR1, TLR2	Toll-like receptor 1, 2
TNFRSF13B	TNF receptor superfamily member 13B
TNFSF13	TNF superfamily member 13
VEGFA	Vascular endothelial growth factor A