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Acc1 and -2 ASO treatment significantly improved hepatic insulin sensitivity in high-fat–fed rats. Peripheral and hepatic insulin sensitivity were assessed by means of hyperinsulinemic-euglycemic clamps (A–C). (A) Glucose infusion rates; (B) peripheral glucose turnover; (C) suppression of HGP during hyperinsulinemic-euglycemic clamps. Data are expressed as mean values ± SEM for 6–9 rats per treatment group. *P < 0.05 versus ASOctrl treatment group.
