FIG. 1.

Diagram of full-length HveA and gD. The amino acid numbers begin with the first amino acid in the mature protein after signal sequence cleavage. The positions of N-glycosylation sites (lollipops) and transmembrane regions (TM) are indicated. The HveA amino acids comprising each of the four CRDs are labeled. The gD amino acids comprising each of four defined functional regions (FR) and the group VII MAb epitope (gray circle) are labeled. The disulfide bond pattern (dotted lines) and locations of cysteines (C) within gD are indicated. Arrows indicate the sites of truncation for the proteins used to solve the crystal structure.