FIGURE 10.

Folded regions of αTS kinetic intermediates. (A) Fraction of native contacts formed with probability >0.5 for intermediates I_120Q (red bars), I_200Q (yellow bars), I_300Q (green bars), and I_360Q (magenta bars) in αTS kinetic folding simulations. (B) Contact map and representative MD structure for I_120Q. Squares in the contact map indicating contacts populated >0.5 and regions in the I_120Q structure with >0.2 fraction of native contacts folded are labeled in red. (C) Contact map and representative MD structure for I_200Q. Squares in the contact map indicating contacts populated >0.5 and regions in the I_200Q structure with >0.2 fraction of native contacts folded are labeled in yellow. (D) Contact map and representative MD structure for I_300Q. Squares in the contact map indicating contacts populated >0.5 and regions in the I_300Q structure with >0.2 fraction of native contacts folded are labeled in green. (E) Contact map and representative MD structure for I_360Q. Squares in the contact map indicating contacts populated >0.5 and regions in the I_360Q structure with >0.2 fraction of native contacts folded are labeled in magenta. In Fig. 5, B–E, squares in the contact maps indicating contacts populated <0.5 and regions of each MD structure with <0.2 fraction of native contacts folded are labeled in black. In Fig. 5, B–E, secondary structure elements of αTS are shown along each axis for reference with folded I_120Q regions colored in red (Fig. 5 B), folded I_200Q regions colored in yellow (Fig. 5 C), folded I_300Q regions colored in green (Fig. 5 D), folded I_360Q regions colored in magenta (Fig. 5 E), and unfolded regions colored in black.