TABLE 1.
N and nH values for documented protein-ligand and enzyme-substrate interactions showing negative cooperativity
| Enzyme | Binding sites/subunits | N | nH | Reference |
|---|---|---|---|---|
| Adenylosuccinate synthase | Dimer | 2 | 0.8 | (16) |
| Human glutathione synthetase | Dimer | 2 | 0.75 | (17) |
| V-ATPase | Hexamer | 6 | 0.16 ±0.03 | (18) |
| NAD-dependent glutamate dehydrogenase | Tetramer | 4 | 0.3 | (19) |
| UDP-GlcNAc 2-epimerase | Hexamer | 6 | 0.45 | (20) |
| Glyceraldehyde-3-phosphate dehydrogenase | Tetramer | 4 | 0.64 | (21) |
| Glutathione-S-transferase P1-1 | Dimer | 2 | 0.65 (5°C) | (22) |
| Metabotropic glutamate receptor | Dimer | 2 | 0.55 | (23) |
| Aspartate kinase | Dimer | 2 | 0.7 | (24) |
| Deoxycytidine kinase | Dimer | 2 | 0.6 | (25) |
| ATP citrate lyase | Tetramer | 4 | 0.45 | (26) |