FIGURE 2.

The minimal distance, in nanometers, between any of the Cl⁻ (A); any of the Na⁺ ions (B); individual Cl⁻ ions (C; each of the four ions is colored differently) or individual Na⁺ ions, and the protein as a function of simulation time, calculated over the simulation MD_N. The distances in nanometers and the time is given in nanoseconds. The absolute minimal distance (∼0.2 nm) is dictated by the steric interferences between the van der Waals radii of the ions.