FIGURE 1.

Snapshots of cells with markers. The markers shown are much larger than the one pixel in the center of a cell's nucleus that is used to denote the position of a cell and on which the marker is centered. Nonmoving cells and cells interfering with each other's trajectories were excluded from the statistics. Length bars measure 200 μm. (Top) HaCaT cells on substrate of molecular collagen. On glass and TCPS they are round in shape. Here they spread out and sometimes show an asymmetric migratory shape. (Bottom) NHDF cells on TCPS. On collagen surfaces they are elongated, whereas on TCPS, and especially on glass, they show a “classical migratory shape” with lamellipodia, riffling membrane, etc.