TABLE 2.

Escape pathways found for selective ligands, different isoforms, and mutants in auxiliary simulations

System	Escape paths found
TRβ with T3	I	I	I	I	I	I
TRβ with GC24	III	III	III	III	III	III
TRβ with IH5	I	I	I	I	III	I
TRα1 with IH5	III	III	I*	I	III	I
TRβ A317T with Triac	II	I	III	II	I	II
TRβ A234T with Triac	II	II	II	II	II	II

All simulations here were performed with 50 copies of the ligand.

^*One of the 50 copies left the binding cavity through Path III.