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. 2005 Jul 22;89(3):2134–2145. doi: 10.1529/biophysj.105.060160

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Copyright © 2005, Biophysical Society

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Dynein-driven movement in the random network implies retrograde movement in a radial one. (A) Schematic view of microtubules in the extract. Plus (blue) and minus (yellow) ends are oriented at random. VirE2-ssDNA complexes are depicted for simplicity as rings. Motor inhibition shows that they move in the plus to minus direction depicted. Because the network is random, however, no net directed movement is induced (). Motor activity may nonetheless be deduced by statistical analysis. (B) Interphase microtubules normally radiate from the centrosome near the nucleus in animal cells. Motor movement becomes retrograde, carrying nuclear-targeted cargo toward the nuclear envelope.

Inline graphic — Dynein-driven movement in the random network implies retrograde movement in a radial one. (A) Schematic view of microtubules in the extract. Plus (blue) and minus (yellow) ends are oriented at random. VirE2-ssDNA complexes are depicted for simplicity as rings. Motor inhibition shows that they move in the plus to minus direction depicted. Because the network is random, however, no net directed movement is induced (). Motor activity may nonetheless be deduced by statistical analysis. (B) Interphase microtubules normally radiate from the centrosome near the nucleus in animal cells. Motor movement becomes retrograde, carrying nuclear-targeted cargo toward the nuclear envelope.