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. 2005 Jul 22;89(3):2134–2145. doi: 10.1529/biophysj.105.060160

TABLE 1.

Summary of mean square displacement measurements, Inline graphic for the VirE2-ssDNA complexes under various treatments of the extracts

Experiment No. Substrate Conditions Prefactor Exponent-γ Movement
1 anVirE2 Untreated 0.59 0.99 Active
2 anVirE2 + AMP-PNP 0.78 0.98 Active
3 anVirE2 + Cytochalasin D 0.51 0.93 Active
4 plVirE2 + Cytochalasin D 1.67 0.97 Passive Brownian
5 plVirE2 + Cytochalasin D + Nocodazole 1.48 0.97 Passive Brownian
6 plVirE2 Untreated 0.32 0.75 Passive restricted
7 anVirE2 + Nocodazole 0.39 0.76 Passive restricted
8 anVirE2 + Vanadate 0.26 0.76 Passive restricted
9 anVirE2 + Antidynein 0.24 0.77 Passive restricted

Note that the measured exponents-γ cluster near either unity or 3/4. Active movement of the anVirE2 complexes (No. 1–3) always shows Inline graphic consistent with directed movement along a random network as explained in the text. Cases of thermally driven motion (No. 4,5) yield Inline graphic when F-actin has been depolymerized and Inline graphic when F-actin is present (No. 6–9).