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Effect of model parameters on cytoplasmic concentrations. (A) Effect of bulk oligonucleotide on cytoplasmic concentration, Ac. Curves correspond to bulk concentrations (Ab) of {200, 400, 600, 800, and 1000} nM. (B) Effect of endosomal escape rate on Ac. Curves correspond to escape rate constants (kt) of {0.001, 0.003, 0.010, and 0.030} min−1.
